HSP90AA1

Across TCGA cell cohorts, HSP90AA1 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. CNS shows the largest number of these associations.

The most reproducible HSP90AA1-associated genes across cancer lineages are APOC3, SPATA16, and OR14A2. Each is linked with HSP90AA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSP90AA1-to-partner and partner-to-HSP90AA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOC3 grouped by HSP90AA1-low versus HSP90AA1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSP90AA1→partner) and Y-score (partner→HSP90AA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	APOC3 →	+0.316	+4.491	<.001	.003	3	1
PANCREAS	SPATA16 →	+0.042	+4.011	<.001	.009	3	1
PANCREAS	OR14A2 →	+0.015	+4.614	<.001	.004	3	1
PANCREAS	OR2S2 →	+0.015	+4.614	<.001	.004	3	1
PANCREAS	TBL1Y →	+0.005	+4.614	<.001	.004	3	1
BLOOD_Lymphoma	SULT1C3 →	+0.012	+4.662	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

APOC3 by HSP90AA1 expression — PANCREAS

Explore this box plot interactively →