Across TCGA patient cohorts, HSH2D RNA expression is significantly associated with the protein abundance of many other proteins, with 17,686 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HSH2D-associated proteins across cancer lineages are ISG20, OAS2, and SP110_S380. Each is linked with HSH2D in more than 9 cancer types. Because this analysis shows association rather than direction, both HSH2D-to-partner and partner-to-HSH2D results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HSH2D→partner) and Y-score (partner→HSH2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ISG20 →	+0.846	+1.359	<.001	<.001	3	10
HNSC	OAS2 →	+0.940	+1.322	<.001	<.001	3	10
LSCC	SP110_S380 →	+0.795	+1.313	<.001	<.001	3	10
COAD	UBE2L6 →	+0.730	+0.659	<.001	<.001	3	10
GBM	MX1 →	+1.030	+0.481	<.001	<.001	3	9
HNSC	NMI →	+0.404	+0.895	.001	.003	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,686 associations by consensus.

Exploration

HSH2D survival (RNA) · tumor vs normal (RNA) · all HSH2D data types