Across TCGA patient cohorts, HSH2D protein abundance is significantly associated with the RNA expression of many other genes, with 13,933 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HSH2D-associated genes across cancer lineages are ZBP1, MZB1, and IGKJ5. Each is linked with HSH2D in more than 4 cancer types. Because this analysis shows association rather than direction, both HSH2D-to-partner and partner-to-HSH2D results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSH2D→partner) and Y-score (partner→HSH2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZBP1 →	+1.355	+1.062	<.001	<.001	3	5
HNSC	MZB1 →	+2.825	+1.074	<.001	<.001	3	5
HNSC	IGKJ5 →	+1.944	+0.933	<.001	<.001	3	5
HNSC	IGHV3-53 →	+2.150	+0.738	<.001	<.001	3	5
HNSC	IGHV4-59 →	+2.420	+0.842	.008	<.001	3	5
BRCA	IGKV3-11 →	+2.077	+0.396	.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,933 associations by consensus.

Exploration

HSH2D survival (RNA) · tumor vs normal (RNA) · all HSH2D data types