Across TCGA patient cohorts, HSH2D mutation is significantly associated with the RNA expression of many other genes, with 1,556 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSH2D-associated genes across cancer lineages are ARHGEF10, ANXA1, and LINC01433. Each is linked with HSH2D in more than 1 cancer types. Because this analysis shows association rather than direction, both HSH2D-to-partner and partner-to-HSH2D results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSH2D→partner) and Y-score (partner→HSH2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARHGEF10 →	+0.661	+2.828	.001	.001	3	2
UCEC	ANXA1 →	+1.250	+3.329	.001	.005	3	2
UCEC	LINC01433 →	+0.244	+2.661	.002	.009	3	2
UCEC	HINT1P1 →	+0.476	+3.337	.002	.005	3	2
UCEC	HMGA1P4 →	+0.645	+3.475	.005	.002	3	2
SKCM	MIR3928 →	+0.461	+2.537	.004	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,556 associations by consensus.

Exploration

HSH2D survival (RNA) · tumor vs normal (RNA) · all HSH2D data types