Across TCGA patient cohorts, HSH2D mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSH2D-associated genes across cancer lineages are FoxM1, Notch1, and p90 RSK. Each is linked with HSH2D in more than 1 cancer types. Because this analysis shows association rather than direction, both HSH2D-to-partner and partner-to-HSH2D results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSH2D→partner) and Y-score (partner→HSH2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.342	+3.321	.011	.010	3	1
UCEC	Notch1 →	+0.195	+3.321	.008	.010	3	1
UCEC	p90 RSK →	+0.203	+2.817	.042	.036	3	1
UCEC	Annexin-1 →	+0.658	+2.827	.017	.035	3	1
UCEC	CD49b →	-0.365	-3.308	.014	.010	1	1
UCEC	Cyclin-B1 →	+0.725	+3.321	.013	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

HSH2D survival (RNA) · tumor vs normal (RNA) · all HSH2D data types