Across TCGA cell cohorts, HSH2D RNA expression is significantly associated with the go_rna of many other GO terms, with 4,382 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible HSH2D-associated GO terms across cancer lineages are Negative regulation of IP-10 production, Maintenance of blood-brain barrier, and Sensory perception of salty taste. Each is linked with HSH2D in more than 12 cancer types. Because this analysis shows association rather than direction, both HSH2D-to-partner and partner-to-HSH2D results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSH2D→partner) and Y-score (partner→HSH2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Negative regulation of IP-10 production →	+0.921	+2.075	<.001	<.001	3	13
PANCREAS	Maintenance of blood-brain barrier →	+0.266	+2.765	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Sensory perception of salty taste →	+1.614	+1.282	<.001	.009	3	12
BLOOD_Myeloma	Pattern recognition receptor signaling pathway →	+0.070	+2.876	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Innate immune response-activating signaling pathway →	+0.067	+1.386	.001	.002	3	12
UPPER_AERODIGESTIVE_TRACT	MDA-5 signaling pathway →	+0.271	+1.663	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,382 associations by consensus.

Exploration

HSH2D survival (RNA) · tumor vs normal (RNA) · all HSH2D data types