HSFX2

Across TCGA patient cohorts, HSFX2 RNA expression is significantly associated with the protein abundance of many other proteins, with 3,421 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HSFX2-associated proteins across cancer lineages are U2SURP_S485, YJU2_S213, and PATL1_S179. Each is linked with HSFX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSFX2-to-partner and partner-to-HSFX2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HSFX2 versus U2SURP_S485 in BRCA, with a Pearson correlation of -0.24.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HSFX2→partner) and Y-score (partner→HSFX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	U2SURP_S485 →	-0.772	-0.220	.002	.003	3	2
GBM	YJU2_S213 →	-0.475	-0.260	.001	.005	3	2
BRCA	PATL1_S179 →	-0.345	-0.228	<.001	<.001	3	2
CCRCC	PFKL →	-0.201	-0.138	.004	.002	3	2
BRCA	PKP4 →	+0.292	+0.222	.004	.001	3	2
BRCA	PLIN2 →	-0.634	-0.228	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,421 associations by consensus.

HSFX2 vs U2SURP_S485 — BRCA

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