HSF5

Across TCGA patient cohorts, HSF5 mutation is significantly associated with the RNA expression of many other genes, with 3,777 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSF5-associated genes across cancer lineages are SEPTIN14P19, DDX52, and MYO19. Each is linked with HSF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSF5-to-partner and partner-to-HSF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN14P19 grouped by HSF5-low versus HSF5-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSF5→partner) and Y-score (partner→HSF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SEPTIN14P19 →	+0.071	+4.822	<.001	.006	3	2
UCEC	DDX52 →	+0.478	+2.413	.002	<.001	3	2
UCEC	MYO19 →	+0.516	+2.392	<.001	<.001	3	2
UCEC	GAS5-AS1 →	+0.428	+2.931	.002	<.001	3	2
UCEC	NUDT3 →	+0.277	+2.254	.006	.005	3	2
UCEC	ZNHIT3 →	+0.563	+2.895	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,777 associations by consensus.

SEPTIN14P19 by HSF5 expression — HNSC

Explore this box plot interactively →