HSF5

Across TCGA patient cohorts, HSF5 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSF5-associated genes across cancer lineages are TFRC, VEGFR2, and Annexin-1. Each is linked with HSF5 in more than 2 cancer types. Because this analysis shows association rather than direction, both HSF5-to-partner and partner-to-HSF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by HSF5-low versus HSF5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSF5→partner) and Y-score (partner→HSF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.522	+3.459	.008	.005	3	3
SKCM	VEGFR2 →	+0.438	+3.000	.004	.036	3	2
UCEC	Annexin-1 →	+0.554	+2.135	.005	.010	3	2
UCEC	ATM →	-0.538	-2.662	.001	<.001	3	2
UCEC	Caspase-8 →	-0.275	-2.973	.003	<.001	3	2
SKCM	AMPK_alpha →	+0.184	+3.000	.022	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

TFRC by HSF5 expression — UCEC

Explore this box plot interactively →