HSF5

Across TCGA cell cohorts, HSF5 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HSF5-associated genes across cancer lineages are IL25, TGM6, and TMEM252. Each is linked with HSF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSF5-to-partner and partner-to-HSF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL25 grouped by HSF5-low versus HSF5-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSF5→partner) and Y-score (partner→HSF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IL25 →	+0.023	+3.672	<.001	.006	3	1
BREAST	TGM6 →	+0.021	+4.312	<.001	.001	3	1
BREAST	TMEM252 →	+0.192	+3.758	<.001	.007	3	1
BREAST	OR52A1 →	+0.022	+3.672	<.001	.006	3	1
BREAST	SLC36A2 →	+0.454	+3.825	<.001	.006	3	1
LUNG_NSCLC_LUAD	GAGE13 →	+1.761	+3.518	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

IL25 by HSF5 expression — BREAST

Explore this box plot interactively →