HSF2

Across TCGA pan-cancer cohorts, HSF2 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HSF2 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HSF2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HSF2 expression acts as an unfavorable survival marker.

HNSC, LUSC, and LUAD are the cancer types where HSF2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.051	0.712	<.001	24	view →
LUSC	OS	Median	III,IV	0.011	0.684	<.001	12	view →
LUAD	DFS	Median	All	0.231	0.678	.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

HSF2–HNSC (OS)

Open the HNSC breakdown →