HSF2

Across TCGA patient cohorts, HSF2 mutation is significantly associated with the RNA expression of many other genes, with 1,157 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSF2-associated genes across cancer lineages are CCT3P1, NEDD8-MDP1, and RNU6-707P. Each is linked with HSF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSF2-to-partner and partner-to-HSF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCT3P1 grouped by HSF2-low versus HSF2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSF2→partner) and Y-score (partner→HSF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CCT3P1 →	+0.052	+4.404	.009	.001	3	2
UCEC	NEDD8-MDP1 →	+0.237	+2.333	<.001	<.001	3	2
STAD	RNU6-707P →	+0.284	+3.403	.003	.006	3	2
STAD	RNU6ATAC19P →	+0.493	+4.187	<.001	.002	3	2
STAD	RN7SKP278 →	+0.115	+4.798	<.001	<.001	3	2
STAD	LINC01688 →	+0.265	+4.345	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,157 associations by consensus.

CCT3P1 by HSF2 expression — LUSC

Explore this box plot interactively →