HSF2

Across TCGA cell cohorts, HSF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,811 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HSF2-associated GO terms across cancer lineages are Regulation of termination of RNA polymerase II transcription, poly(A)-coupled, Regulation of termination of RNA polymerase II transcription, and Regulation of termination of DNA-templated transcription. Each is linked with HSF2 in more than 17 cancer types. Because this analysis shows association rather than direction, both HSF2-to-partner and partner-to-HSF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of termination of RNA polymerase II transcription, poly(A)-coupled grouped by HSF2-low versus HSF2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSF2→partner) and Y-score (partner→HSF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of termination of RNA polymerase II transcription, poly(A)-coupled →	+0.151	+0.951	.002	<.001	3	18
STOMACH	Regulation of termination of RNA polymerase II transcription →	+0.157	+1.058	.001	<.001	3	17
STOMACH	Regulation of termination of DNA-templated transcription →	+0.157	+1.058	.001	<.001	3	17
SOFT_TISSUE	Termination of RNA polymerase II transcription →	+0.124	+1.098	<.001	.002	1	18
URINARY_TRACT	Regulation of chromosome organization →	+0.080	+0.935	<.001	.002	3	16
BLOOD_Myeloma	DNA-templated DNA replication →	+0.100	+0.798	.004	.004	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,811 associations by consensus.

Regulation of termination of RNA polymerase II transcription, poly(A)-coupled by HSF2 expression — STOMACH

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