HSF2

Across TCGA cell cohorts, HSF2 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible HSF2-associated genes across cancer lineages are NXF5, GSC2, and IL20. Each is linked with HSF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSF2-to-partner and partner-to-HSF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NXF5 grouped by HSF2-low versus HSF2-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSF2→partner) and Y-score (partner→HSF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	NXF5 →	+0.029	+3.794	.004	.003	3	1
STOMACH	GSC2 →	+0.026	+3.432	.005	.008	3	1
LARGE_INTESTINE	IL20 →	+0.275	+3.662	<.001	.009	2	2

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

NXF5 by HSF2 expression — STOMACH

Explore this box plot interactively →