Across TCGA patient cohorts, HSF1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,090 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HSF1-associated proteins across cancer lineages are SCRIB, PYCR3, and NUDCD1. Each is linked with HSF1 in more than 7 cancer types. Because this analysis shows association rather than direction, both HSF1-to-partner and partner-to-HSF1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HSF1→partner) and Y-score (partner→HSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SCRIB →	+0.344	+0.682	<.001	<.001	3	8
LSCC	PYCR3 →	+0.435	+0.656	<.001	<.001	3	7
BRCA	NUDCD1 →	+0.325	+0.482	<.001	.003	3	6
LSCC	PUF60 →	+0.212	+0.390	<.001	<.001	3	5
PDAC	UTP15 →	+0.274	+0.430	<.001	<.001	3	5
BRCA	HGH1 →	+0.333	+0.690	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,090 associations by consensus.

Exploration

HSF1 survival (RNA) · tumor vs normal (RNA) · all HSF1 data types