Across TCGA patient cohorts, HSF1 protein abundance is significantly associated with the RNA expression of many other genes, with 11,141 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HSF1-associated genes across cancer lineages are ZNF623, MED30, and ZNF7. Each is linked with HSF1 in more than 6 cancer types. Because this analysis shows association rather than direction, both HSF1-to-partner and partner-to-HSF1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSF1→partner) and Y-score (partner→HSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZNF623 →	+0.755	+0.718	.004	.008	3	7
BRCA	MED30 →	+0.637	+0.311	<.001	<.001	3	7
BRCA	ZNF7 →	+0.551	+0.468	<.001	<.001	3	7
OV	LRRC14 →	+0.843	+0.703	.002	.009	3	6
OV	HGH1 →	+0.863	+0.767	.001	<.001	3	6
BRCA	CYHR1 →	+0.735	+0.380	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,141 associations by consensus.

Exploration

HSF1 survival (RNA) · tumor vs normal (RNA) · all HSF1 data types