Across TCGA patient cohorts, HSF1 mutation is significantly associated with the RNA expression of many other genes, with 147 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSF1-associated genes across cancer lineages are PIGQP1, PMS2P11, and RNU5A-3P. Each is linked with HSF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSF1-to-partner and partner-to-HSF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSF1→partner) and Y-score (partner→HSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	PIGQP1 →	+0.117	+6.479	<.001	.001	3	2
UCEC	PMS2P11 →	+0.090	+3.318	<.001	<.001	3	2
UCEC	RNU5A-3P →	+0.347	+3.163	.004	.001	3	2
UCEC	UTP15 →	+0.575	+3.245	.003	.009	3	1
UCEC	HSFX1 →	+0.119	+3.714	<.001	.004	3	1
SKCM	HUNK-AS1 →	+0.049	+3.186	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 147 associations by consensus.

Exploration

HSF1 survival (RNA) · tumor vs normal (RNA) · all HSF1 data types