Across TCGA patient cohorts, HSF1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSF1-associated genes across cancer lineages are Rad50, p27, and Di-Ras3. Each is linked with HSF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSF1-to-partner and partner-to-HSF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSF1→partner) and Y-score (partner→HSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.394	-3.000	.004	.037	2	2
UCEC	p27 →	+0.365	+3.000	.003	.037	1	2
UCEC	Di-Ras3 →	-0.277	-3.000	.001	.037	2	1
UCEC	p62 Lck ligand →	+0.554	+3.000	.003	.037	1	1
UCEC	Cyclin-B1 →	+0.775	+3.000	.016	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

HSF1 survival (RNA) · tumor vs normal (RNA) · all HSF1 data types