Across TCGA cell cohorts, HSF1 mutation is significantly associated with the protein abundance of many other proteins, with 49 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HSF1-associated proteins across cancer lineages are RPS7, DRAP1, and KIF2A. Each is linked with HSF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSF1-to-partner and partner-to-HSF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HSF1→partner) and Y-score (partner→HSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RPS7 →	-0.305	-3.139	.004	.008	3	1
BLOOD_Leukemia	DRAP1 →	+0.602	+3.226	.009	.004	3	1
BLOOD_Leukemia	KIF2A →	+0.547	+3.224	.003	.005	3	1
BLOOD_Leukemia	ERH →	+0.394	+3.115	.004	.009	3	1
BLOOD_Leukemia	AHCY →	-0.426	-3.285	.005	.006	3	1
BLOOD_Leukemia	SNRPA1 →	+0.321	+3.431	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Exploration

HSF1 survival (RNA) · tumor vs normal (RNA) · all HSF1 data types