HSDL2

Across TCGA patient cohorts, HSDL2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSDL2-associated genes across cancer lineages are SCD, Shc_pY317, and CD49b. Each is linked with HSDL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSDL2-to-partner and partner-to-HSDL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCD grouped by HSDL2-low versus HSDL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSDL2→partner) and Y-score (partner→HSDL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SCD →	-0.168	-2.990	.003	.036	3	1
UCEC	Shc_pY317 →	-0.193	-3.321	.015	.010	3	1
UCEC	CD49b →	-0.475	-3.150	.001	.019	3	1
UCEC	Gab2 →	+0.380	+3.321	.042	.010	2	1
UCEC	Axl →	+0.286	+2.818	.016	.035	2	1
UCEC	VHL →	-1.097	-3.000	.002	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

SCD by HSDL2 expression — UCEC

Explore this box plot interactively →