HSDL1

Across TCGA pan-cancer cohorts, HSDL1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HSDL1 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher HSDL1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HSDL1 expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

PDAC, GBM, and CCRCC are the cancer types where HSDL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.610	0.831	.004	21	view →
GBM	DFS	Tertile	All	0.869	0.613	<.001	15	view →
CCRCC	DFS	Median	II,III,IV	0.445	0.765	.002	11	view →
LUAD	DFS	Tertile	III,IV	0.580	0.840	.049	3	view →
HNSC	OS	Quartile	III,IV	0.808	0.531	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HSDL1–PDAC (DFS)

Open the PDAC breakdown →