HSD3B7

Across TCGA pan-cancer cohorts, HSD3B7 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of HSD3B7’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where HSD3B7 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types HSD3B7 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

CCRCC, LSCC, and LUAD are the cancer types where HSD3B7 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSD3B7 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	+1.178	<.001	12	view →
LSCC	All	All	−0.385	<.001	5	view →
LUAD	Male	All	−0.316	<.001	5	view →
OV	All	All	−1.157	.029	2	view →
PDAC	All	All	−0.430	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

HSD3B7–CCRCC

Open the CCRCC breakdown →