HSD3B7

Across TCGA patient cohorts, HSD3B7 mutation is significantly associated with the RNA expression of many other genes, with 244 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSD3B7-associated genes across cancer lineages are F8A2, DUSP12P1, and OR7A17. Each is linked with HSD3B7 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD3B7-to-partner and partner-to-HSD3B7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, F8A2 grouped by HSD3B7-low versus HSD3B7-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD3B7→partner) and Y-score (partner→HSD3B7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	F8A2 →	+0.074	+4.926	<.001	.002	3	2
BRCA	DUSP12P1 →	+0.235	+5.409	<.001	.005	3	1
BRCA	OR7A17 →	+0.041	+6.442	<.001	.001	3	1
BRCA	RNU6-1097P →	+0.164	+7.471	<.001	.008	3	1
BRCA	GLT6D1 →	+0.073	+5.473	<.001	.005	3	1
BRCA	LINC00376 →	+0.089	+5.317	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 244 associations by consensus.

F8A2 by HSD3B7 expression — LUAD

Explore this box plot interactively →