HSD3B7

Across TCGA cell cohorts, HSD3B7 mutation is significantly associated with the mutation status of many other genes, with 217 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HSD3B7-associated genes across cancer lineages are DDX1, TRAK2, and CSE1L. Each is linked with HSD3B7 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD3B7-to-partner and partner-to-HSD3B7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DDX1 grouped by HSD3B7-low versus HSD3B7-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD3B7→partner) and Y-score (partner→HSD3B7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DDX1 →	+4.309	+4.560	.007	.007	1	2
STOMACH	TRAK2 →	+4.807	+4.807	.008	.008	1	2
STOMACH	CSE1L →	+4.807	+4.807	.008	.008	1	2
STOMACH	PPP4R1L →	+4.807	+4.807	.008	.008	1	2
STOMACH	PTCD3 →	+4.807	+4.807	.008	.008	1	2
STOMACH	CREBZF →	+4.807	+4.807	.008	.008	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 217 associations by consensus.

DDX1 by HSD3B7 expression — BLOOD_Leukemia

Explore this box plot interactively →