Across TCGA pan-cancer cohorts, HSD3B1 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of HSD3B1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HSD3B1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types HSD3B1 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

HNSC and CCRCC are the cancer types where HSD3B1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSD3B1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	−0.451	.020	4	view →
CCRCC	All	All	+0.197	.033	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: HSD3B1 RNA expression & survival · all HSD3B1 data types