Across TCGA patient cohorts, HSD3B1 mutation is significantly associated with the RNA expression of many other genes, with 1,560 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSD3B1-associated genes across cancer lineages are RTCB, LRRC59, and PSMD9. Each is linked with HSD3B1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HSD3B1-to-partner and partner-to-HSD3B1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD3B1→partner) and Y-score (partner→HSD3B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RTCB →	+0.460	+1.960	.008	.009	3	3
UCEC	LRRC59 →	+0.476	+3.815	.006	<.001	3	3
UCEC	PSMD9 →	+0.490	+3.716	<.001	<.001	3	3
UCEC	NARS1 →	+0.460	+2.617	.005	.005	3	3
UCEC	SURF4 →	+0.573	+3.708	<.001	<.001	3	3
UCEC	PDF →	+0.799	+3.609	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,560 associations by consensus.

Exploration

HSD3B1 survival (RNA) · tumor vs normal (RNA) · all HSD3B1 data types