HSD17B7P2

Across TCGA patient cohorts, HSD17B7P2 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible HSD17B7P2-associated genes across cancer lineages are 14-3-3_zeta, 4E-BP1, and N-Ras. Each is linked with HSD17B7P2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HSD17B7P2-to-partner and partner-to-HSD17B7P2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_zeta grouped by HSD17B7P2-low versus HSD17B7P2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B7P2→partner) and Y-score (partner→HSD17B7P2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	14-3-3_zeta →	+0.632	+2.853	<.001	.034	3	3
LUSC	4E-BP1 →	+1.065	+2.821	<.001	.035	3	3
UCEC	N-Ras →	-0.166	-2.986	.015	.037	3	2
LUSC	eIF4E →	+0.189	+2.816	.023	.036	3	1
LUSC	PAI-1 →	+0.844	+2.816	.020	.036	3	1
LUSC	Smad4 →	+0.153	+2.816	.007	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

14-3-3_zeta by HSD17B7P2 expression — LUSC

Explore this box plot interactively →