HSD17B7

Across TCGA patient cohorts, HSD17B7 mutation is significantly associated with the RNA expression of many other genes, with 330 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSD17B7-associated genes across cancer lineages are RNU1-17P, TMEM252, and NOP10. Each is linked with HSD17B7 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD17B7-to-partner and partner-to-HSD17B7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-17P grouped by HSD17B7-low versus HSD17B7-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B7→partner) and Y-score (partner→HSD17B7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU1-17P →	+0.462	+5.103	<.001	.008	3	2
UCEC	TMEM252 →	+1.696	+3.512	<.001	.002	3	1
UCEC	NOP10 →	+0.465	+2.700	.004	.006	3	1
UCEC	DDX41 →	+0.365	+3.491	.009	.002	3	1
UCEC	NDUFA6 →	+0.515	+2.632	<.001	.005	3	1
UCEC	RN7SL219P →	+0.363	+3.298	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 330 associations by consensus.

RNU1-17P by HSD17B7 expression — CESC

Explore this box plot interactively →