HSD17B7

Across TCGA patient cohorts, HSD17B7 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSD17B7-associated genes across cancer lineages are MEP, Mesangial cells, and pDC. Each is linked with HSD17B7 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD17B7-to-partner and partner-to-HSD17B7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEP grouped by HSD17B7-low versus HSD17B7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B7→partner) and Y-score (partner→HSD17B7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEP →	+0.027	+2.010	.032	.019	3	1
UCEC	Mesangial cells →	-0.043	-2.689	.014	.006	3	1
UCEC	pDC →	+0.045	+3.032	.041	.018	3	1
UCEC	Class-switched memory B-cells →	-0.062	-3.807	.016	<.001	2	1
UCEC	Macrophages M2 →	+0.014	+2.118	.003	.016	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MEP by HSD17B7 expression — UCEC

Explore this box plot interactively →