HSD17B4

Across TCGA patient cohorts, HSD17B4 protein abundance is significantly associated with the RNA expression of many other genes, with 17,536 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible HSD17B4-associated genes across cancer lineages are GLB1, BRMS1L, and CYSTM1. Each is linked with HSD17B4 in more than 4 cancer types. Because this analysis shows association rather than direction, both HSD17B4-to-partner and partner-to-HSD17B4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HSD17B4 versus GLB1 in UCEC, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B4→partner) and Y-score (partner→HSD17B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GLB1 →	+0.542	+0.228	.001	.005	3	5
HNSC	BRMS1L →	-0.513	-0.236	.003	<.001	3	5
UCEC	CYSTM1 →	+0.959	+0.429	<.001	<.001	3	5
UCEC	UQCRQ →	+0.828	+0.372	.002	.001	3	5
LSCC	DENND2D →	+0.535	+0.406	<.001	<.001	3	5
UCEC	TXN →	+0.893	+0.336	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,536 associations by consensus.

HSD17B4 vs GLB1 — UCEC

Explore this scatter interactively →