HSD17B4

Across TCGA patient cohorts, HSD17B4 mutation is significantly associated with the RNA expression of many other genes, with 2,034 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSD17B4-associated genes across cancer lineages are ATP5MGP3, RPL22P22, and CIDECP1. Each is linked with HSD17B4 in more than 2 cancer types. Because this analysis shows association rather than direction, both HSD17B4-to-partner and partner-to-HSD17B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP5MGP3 grouped by HSD17B4-low versus HSD17B4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B4→partner) and Y-score (partner→HSD17B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP5MGP3 →	+0.434	+3.917	<.001	<.001	3	3
LUSC	RPL22P22 →	+0.250	+4.006	.001	.001	3	2
UCEC	CIDECP1 →	+0.466	+2.053	<.001	<.001	3	2
UCEC	GTF2E2 →	+0.397	+2.431	<.001	.001	3	2
UCEC	RNU6-879P →	+0.343	+1.793	<.001	.001	3	2
UCEC	NAP1L4 →	+0.362	+2.343	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,034 associations by consensus.

ATP5MGP3 by HSD17B4 expression — UCEC

Explore this box plot interactively →