HSD17B4

Across TCGA patient cohorts, HSD17B4 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSD17B4-associated genes across cancer lineages are Notch1, JNK_pT183_Y185, and 14-3-3_beta. Each is linked with HSD17B4 in more than 3 cancer types. Because this analysis shows association rather than direction, both HSD17B4-to-partner and partner-to-HSD17B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by HSD17B4-low versus HSD17B4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B4→partner) and Y-score (partner→HSD17B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.147	+2.820	.003	.001	3	4
UCEC	JNK_pT183_Y185 →	-0.167	-3.906	.005	<.001	3	2
UCEC	14-3-3_beta →	-0.084	-2.088	.017	.016	3	1
UCEC	ACVRL1 →	-0.104	-1.861	.030	.049	3	1
UCEC	JNK2 →	+0.161	+2.000	.021	.003	3	1
UCEC	p90 RSK →	+0.158	+1.375	.019	.024	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Notch1 by HSD17B4 expression — UCEC

Explore this box plot interactively →