HSD17B4

Across TCGA cell cohorts, HSD17B4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,661 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HSD17B4-associated GO terms across cancer lineages are NAD-cap decapping, Positive regulation of centrosome duplication, and Branched-chain amino acid metabolic process. Each is linked with HSD17B4 in more than 8 cancer types. Because this analysis shows association rather than direction, both HSD17B4-to-partner and partner-to-HSD17B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NAD-cap decapping grouped by HSD17B4-low versus HSD17B4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B4→partner) and Y-score (partner→HSD17B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NAD-cap decapping →	+0.093	+0.852	.006	.003	3	9
PANCREAS	Positive regulation of centrosome duplication →	+0.086	+0.568	<.001	.006	3	9
LIVER	Branched-chain amino acid metabolic process →	+0.102	+0.839	.001	<.001	3	9
LIVER	Branched-chain amino acid catabolic process →	+0.125	+0.916	.001	<.001	3	9
BLOOD_Myeloma	Aerobic electron transport chain →	+0.093	+0.721	.003	.002	2	8
LUNG_NSCLC_LUSC	Medium-chain fatty-acyl-CoA metabolic process →	+0.117	+0.938	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,661 associations by consensus.

NAD-cap decapping by HSD17B4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →