HSD17B4

Across TCGA cell cohorts, HSD17B4 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HSD17B4-associated genes across cancer lineages are NOTO, MROH2B, and TBATA. Each is linked with HSD17B4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD17B4-to-partner and partner-to-HSD17B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOTO grouped by HSD17B4-low versus HSD17B4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B4→partner) and Y-score (partner→HSD17B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NOTO →	+0.024	+5.199	<.001	<.001	3	2
BLOOD_Lymphoma	MROH2B →	+0.050	+4.058	<.001	.009	3	2
OVARY	TBATA →	+0.193	+4.700	<.001	.002	3	1
SKIN	GGTLC2 →	+0.027	+3.688	<.001	.002	3	1
SKIN	SLC7A10 →	+0.257	+3.510	<.001	.003	3	1
SKIN	DYTN →	+0.071	+3.632	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

NOTO by HSD17B4 expression — SKIN

Explore this box plot interactively →