HSD17B3-AS1

Across TCGA pan-cancer cohorts, HSD17B3-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated HSD17B3-AS1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher HSD17B3-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HSD17B3-AS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and READ show a favorable association.

KICH, LGG, and UVM are the cancer types where HSD17B3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.729	0.976	<.001	108	view →
LGG	DFS	Median	All	0.659	0.806	<.001	41	view →
UVM	DFS	Median	III,IV	0.230	0.790	<.001	29	view →
BLCA	DFS	Quartile	IV	0.628	0.407	.016	24	view →
READ	OS	Median	IV	0.913	0.508	.003	22	view →
UCS	OS	Tertile	All	0.485	0.752	.024	16	view →
KIRC	DFS	Quartile	All	0.462	0.686	.008	16	view →
KIRP	DFS	Quartile	All	0.760	0.903	.009	14	view →
CHOL	OS	Quartile	All	0.164	0.861	.024	12	view →
PRAD	OS	Median	All	0.977	1.000	.014	12	view →
ACC	DFS	Median	All	0.451	0.758	.003	11	view →
SKCM	OS	Quartile	All	0.663	0.361	.017	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

HSD17B3-AS1–KICH (DFS)

Open the KICH breakdown →