HSD17B2

Across TCGA patient cohorts, HSD17B2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSD17B2-associated genes across cancer lineages are Bak, Cyclin-E2, and EGFR_pY1068. Each is linked with HSD17B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD17B2-to-partner and partner-to-HSD17B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bak grouped by HSD17B2-low versus HSD17B2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B2→partner) and Y-score (partner→HSD17B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bak →	+0.350	+3.700	.002	.001	3	2
UCEC	Cyclin-E2 →	+0.231	+3.179	.003	.010	3	2
UCEC	EGFR_pY1068 →	-0.328	-3.169	.005	.018	3	1
UCEC	A-Raf_pS299 →	-0.162	-2.999	.003	.035	3	1
UCEC	FASN →	+0.401	+2.584	.029	.011	3	1
UCEC	GAPDH →	+0.626	+2.999	.012	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Bak by HSD17B2 expression — UCEC

Explore this box plot interactively →