HSD17B2

Across TCGA cell cohorts, HSD17B2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,839 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible HSD17B2-associated GO terms across cancer lineages are Neuroendocrine cell differentiation, Regulation of tolerance induction dependent upon immune response, and Regulation of potassium ion import. Each is linked with HSD17B2 in more than 8 cancer types. Because this analysis shows association rather than direction, both HSD17B2-to-partner and partner-to-HSD17B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neuroendocrine cell differentiation grouped by HSD17B2-low versus HSD17B2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B2→partner) and Y-score (partner→HSD17B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Neuroendocrine cell differentiation →	-0.225	-0.774	.001	.009	3	8
STOMACH	Regulation of tolerance induction dependent upon immune response →	+1.137	+3.266	.004	.001	2	9
STOMACH	Regulation of potassium ion import →	+0.202	+2.328	<.001	<.001	3	7
KIDNEY	Endosome organization →	+0.069	+0.734	.002	.002	3	6
STOMACH	Positive regulation of sodium ion transmembrane transport →	+0.297	+3.762	<.001	<.001	3	6
LIVER	Regulation of cytotoxic T cell degranulation →	+1.882	+2.652	<.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,839 associations by consensus.

Neuroendocrine cell differentiation by HSD17B2 expression — SOFT_TISSUE

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