HSD17B2

Across TCGA cell cohorts, HSD17B2 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HSD17B2-associated genes across cancer lineages are OPRM1, DMRTB1, and PABPC1L2A. Each is linked with HSD17B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD17B2-to-partner and partner-to-HSD17B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPRM1 grouped by HSD17B2-low versus HSD17B2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B2→partner) and Y-score (partner→HSD17B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OPRM1 →	+0.028	+4.169	<.001	.008	3	1
CNS	DMRTB1 →	+0.018	+4.643	<.001	.003	3	1
CNS	PABPC1L2A →	+0.035	+4.321	<.001	.009	3	1
CNS	PRSS58 →	+0.068	+5.285	<.001	<.001	3	1
SKIN	OR2B2 →	+0.027	+4.684	<.001	.002	3	1
SKIN	EDDM3B →	+0.029	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

OPRM1 by HSD17B2 expression — CNS

Explore this box plot interactively →