HSD17B1P1

Across TCGA pan-cancer cohorts, HSD17B1P1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated HSD17B1P1 data layer compared with 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HSD17B1P1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated HSD17B1P1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UVM show a favorable association.

HNSC, UVM, and ACC are the cancer types where HSD17B1P1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.445	0.242	<.001	102	view →
UVM	OS	Tertile	All	0.958	0.345	<.001	71	view →
ACC	DFS	Tertile	All	0.214	0.707	<.001	63	view →
PAAD	OS	Tertile	All	0.609	0.239	<.001	63	view →
KICH	OS	Median	III,IV	0.759	1.000	.004	49	view →
LUSC	DFS	Median	III,IV	0.484	0.946	.002	46	view →
KIRP	DFS	Tertile	IV	0.140	0.574	.004	44	view →
LIHC	DFS	Median	All	0.465	0.615	<.001	22	view →
BRCA	DFS	Median	IV	0.285	0.732	.001	20	view →
LGG	OS	Median	All	0.862	0.755	<.001	19	view →
BLCA	OS	Quartile	All	0.839	0.698	.016	19	view →
LUAD	DFS	Median	III,IV	0.309	0.620	.004	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

HSD17B1P1–HNSC (DFS)

Open the HNSC breakdown →