HSD17B13

Across TCGA patient cohorts, HSD17B13 protein abundance is significantly associated with the RNA expression of many other genes, with 1,485 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible HSD17B13-associated genes across cancer lineages are HMGCS2, LINC01819, and SPATA6L. Each is linked with HSD17B13 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD17B13-to-partner and partner-to-HSD17B13 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HSD17B13 versus HMGCS2 in CCRCC, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B13→partner) and Y-score (partner→HSD17B13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HMGCS2 →	+3.294	+1.322	<.001	.002	3	2
LUAD	LINC01819 →	+0.320	+0.551	<.001	<.001	3	2
LSCC	SPATA6L →	+0.638	+0.645	<.001	.001	3	2
LSCC	TSPAN1 →	+1.446	+0.769	.002	<.001	3	2
LSCC	CFAP94 →	+0.991	+0.571	.002	.008	3	2
LUAD	SLPI →	+1.419	+0.748	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,485 associations by consensus.

HSD17B13 vs HMGCS2 — CCRCC

Explore this scatter interactively →