HSD17B13

Across TCGA patient cohorts, HSD17B13 mutation is significantly associated with the RNA expression of many other genes, with 109 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible HSD17B13-associated genes across cancer lineages are RNA5SP55, OFD1P3Y, and RPL7L1P4. Each is linked with HSD17B13 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD17B13-to-partner and partner-to-HSD17B13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP55 grouped by HSD17B13-low versus HSD17B13-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B13→partner) and Y-score (partner→HSD17B13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNA5SP55 →	+0.421	+4.790	<.001	.006	3	2
BLCA	OFD1P3Y →	+0.045	+5.018	.002	.004	3	2
UCEC	RPL7L1P4 →	+0.226	+3.255	<.001	.003	3	2
UCEC	NUDT4B →	+0.083	+3.884	<.001	.002	3	1
BLCA	C1GALT1P3 →	+0.046	+4.788	<.001	.006	3	1
BLCA	OR2AL1P →	+0.077	+5.814	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 109 associations by consensus.

RNA5SP55 by HSD17B13 expression — COAD

Explore this box plot interactively →