HSD17B13

Across TCGA cell cohorts, HSD17B13 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,892 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HSD17B13-associated GO terms across cancer lineages are Regulation of syncytium formation by plasma membrane fusion, Negative regulation of myoblast fusion, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with HSD17B13 in more than 7 cancer types. Because this analysis shows association rather than direction, both HSD17B13-to-partner and partner-to-HSD17B13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of syncytium formation by plasma membrane fusion grouped by HSD17B13-low versus HSD17B13-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B13→partner) and Y-score (partner→HSD17B13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of syncytium formation by plasma membrane fusion →	+0.092	+0.171	<.001	.006	3	8
KIDNEY	Negative regulation of myoblast fusion →	+0.087	+0.186	.003	.005	3	8
KIDNEY	Negative regulation of syncytium formation by plasma membrane fusion →	+0.090	+0.153	<.001	.007	3	8
KIDNEY	Regulation of myoblast fusion →	+0.091	+0.165	<.001	.007	3	7
UPPER_AERODIGESTIVE_TRACT	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway →	-0.053	-0.087	.006	.008	3	6
LIVER	Fatty acid beta-oxidation →	+0.118	+0.156	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,892 associations by consensus.

Regulation of syncytium formation by plasma membrane fusion by HSD17B13 expression — KIDNEY

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