HSD17B13

Across TCGA cell cohorts, HSD17B13 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible HSD17B13-associated genes across cancer lineages are OR2L5, GLT6D1, and CSHL1. Each is linked with HSD17B13 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD17B13-to-partner and partner-to-HSD17B13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2L5 grouped by HSD17B13-low versus HSD17B13-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B13→partner) and Y-score (partner→HSD17B13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2L5 →	+0.019	+5.472	<.001	<.001	3	1
LUNG_NSCLC_LUAD	GLT6D1 →	+0.004	+4.662	<.001	.005	3	1
LARGE_INTESTINE	CSHL1 →	+0.024	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR2L5 by HSD17B13 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →