HSD17B12

Across TCGA patient cohorts, HSD17B12 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,162 significant associations in total. THYM shows the largest number of these associations.

The most reproducible HSD17B12-associated GO terms across cancer lineages are 5S class rRNA transcription by RNA polymerase III, Citrate metabolic process, and Ribosome-associated ubiquitin-dependent protein catabolic process. Each is linked with HSD17B12 in more than 28 cancer types. Because this analysis shows association rather than direction, both HSD17B12-to-partner and partner-to-HSD17B12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 5S class rRNA transcription by RNA polymerase III grouped by HSD17B12-low versus HSD17B12-high in CHOL.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B12→partner) and Y-score (partner→HSD17B12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	5S class rRNA transcription by RNA polymerase III →	+0.073	+1.476	<.001	<.001	1	29
UCEC	Citrate metabolic process →	+0.058	+0.697	<.001	<.001	3	27
THYM	Ribosome-associated ubiquitin-dependent protein catabolic process →	+0.081	+0.708	<.001	<.001	3	26
UVM	Error-prone translesion synthesis →	+0.075	+1.530	<.001	<.001	3	26
UVM	Regulation of centriole replication →	+0.064	+1.524	<.001	<.001	3	26
UVM	Positive regulation of mRNA processing →	+0.078	+1.553	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,162 associations by consensus.

5S class rRNA transcription by RNA polymerase III by HSD17B12 expression — CHOL

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