HSD17B12

Across TCGA patient cohorts, HSD17B12 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSD17B12-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, MEK1, and p62 Lck ligand. Each is linked with HSD17B12 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD17B12-to-partner and partner-to-HSD17B12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by HSD17B12-low versus HSD17B12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B12→partner) and Y-score (partner→HSD17B12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.468	+2.179	.041	.034	3	1
UCEC	MEK1 →	+0.424	+2.700	.010	.006	3	1
UCEC	p62 Lck ligand →	+0.440	+2.999	.002	.035	3	1
UCEC	Rab11 →	-0.133	-2.000	.042	.032	3	1
UCEC	Rictor_pT1135 →	-0.108	-2.000	.019	.032	3	1
UCEC	Tuberin →	+0.326	+2.000	.007	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Acetyl-a-Tubulin-Lys40 by HSD17B12 expression — UCEC

Explore this box plot interactively →