HSD17B12

Across TCGA cell cohorts, HSD17B12 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,493 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HSD17B12-associated GO terms across cancer lineages are Fatty acid elongation, saturated fatty acid, Fatty acid elongation, and Pyruvate decarboxylation to acetyl-CoA. Each is linked with HSD17B12 in more than 13 cancer types. Because this analysis shows association rather than direction, both HSD17B12-to-partner and partner-to-HSD17B12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fatty acid elongation, saturated fatty acid grouped by HSD17B12-low versus HSD17B12-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B12→partner) and Y-score (partner→HSD17B12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Fatty acid elongation, saturated fatty acid →	+0.225	+2.763	.003	.004	3	14
STOMACH	Fatty acid elongation →	+0.169	+2.971	.001	.002	3	11
UPPER_AERODIGESTIVE_TRACT	Pyruvate decarboxylation to acetyl-CoA →	+0.125	+0.864	.003	<.001	2	9
PANCREAS	Regulation of protection from non-homologous end joining at telomere →	-0.122	-0.764	<.001	<.001	3	7
PANCREAS	Negative regulation of protection from non-homologous end joining at telomere →	-0.122	-0.764	<.001	<.001	3	7
PANCREAS	Telomeric DNA-containing double minutes formation →	-0.122	-0.764	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,493 associations by consensus.

Fatty acid elongation, saturated fatty acid by HSD17B12 expression — STOMACH

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