HSD17B1

Across TCGA patient cohorts, HSD17B1 mutation is significantly associated with the RNA expression of many other genes, with 250 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSD17B1-associated genes across cancer lineages are SNORA36A, MIR340, and MIR450A2. Each is linked with HSD17B1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HSD17B1-to-partner and partner-to-HSD17B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORA36A grouped by HSD17B1-low versus HSD17B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B1→partner) and Y-score (partner→HSD17B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNORA36A →	+0.575	+2.172	.001	.006	3	3
LUSC	MIR340 →	+0.312	+3.919	.001	.006	3	2
BLCA	MIR450A2 →	+0.191	+5.311	<.001	.001	3	2
SKCM	SNORA10B →	+0.289	+4.979	<.001	.009	3	2
UCEC	RNU6ATAC3P →	+0.256	+2.376	.002	.007	3	2
UCEC	MIR6854 →	+0.249	+3.707	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 250 associations by consensus.

SNORA36A by HSD17B1 expression — UCEC

Explore this box plot interactively →