HSD17B1

Across TCGA patient cohorts, HSD17B1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSD17B1-associated genes across cancer lineages are Ku80, p27_pT157, and YB-1. Each is linked with HSD17B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD17B1-to-partner and partner-to-HSD17B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by HSD17B1-low versus HSD17B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B1→partner) and Y-score (partner→HSD17B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.239	+3.009	.036	.019	3	1
UCEC	p27_pT157 →	-0.061	-2.459	.030	.020	3	1
UCEC	YB-1 →	-0.222	-2.432	.003	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+0.653	+3.189	.022	.010	3	1
UCEC	c-Myc →	-0.234	-2.446	.049	.020	3	1
UCEC	Annexin_VII →	-0.134	-2.459	.045	.020	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Ku80 by HSD17B1 expression — UCEC

Explore this box plot interactively →