HSD17B1

Across TCGA cell cohorts, HSD17B1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,766 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HSD17B1-associated GO terms across cancer lineages are Copper ion export, Calcium-independent cell-matrix adhesion, and Negative regulation of purine nucleotide biosynthetic process. Each is linked with HSD17B1 in more than 8 cancer types. Because this analysis shows association rather than direction, both HSD17B1-to-partner and partner-to-HSD17B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Copper ion export grouped by HSD17B1-low versus HSD17B1-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B1→partner) and Y-score (partner→HSD17B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Copper ion export →	-0.151	-0.441	<.001	<.001	3	9
LARGE_INTESTINE	Calcium-independent cell-matrix adhesion →	+0.204	+1.065	<.001	.003	3	9
SOFT_TISSUE	Negative regulation of purine nucleotide biosynthetic process →	+0.160	+1.404	<.001	.001	3	9
SOFT_TISSUE	Negative regulation of nucleotide biosynthetic process →	+0.160	+1.404	<.001	.001	3	9
CNS	Transport along microtubule →	+0.041	+0.529	<.001	<.001	3	9
SOFT_TISSUE	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process →	+0.039	+1.426	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,766 associations by consensus.

Copper ion export by HSD17B1 expression — BLOOD_Leukemia

Explore this box plot interactively →