HSD17B1

Across TCGA cell cohorts, HSD17B1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HSD17B1-associated genes across cancer lineages are ODF1, WFDC12, and CTRB2. Each is linked with HSD17B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSD17B1-to-partner and partner-to-HSD17B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ODF1 grouped by HSD17B1-low versus HSD17B1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSD17B1→partner) and Y-score (partner→HSD17B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ODF1 →	+0.064	+3.944	.001	.006	3	1
BLOOD_Leukemia	WFDC12 →	+0.198	+3.874	<.001	.005	3	1
BLOOD_Leukemia	CTRB2 →	+0.081	+3.855	.001	.007	3	1
BLOOD_Leukemia	DEFB4A →	+0.096	+4.269	.001	.002	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	FAM205A →	+0.019	+3.766	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ODF1 by HSD17B1 expression — BLOOD_Leukemia

Explore this box plot interactively →